Recombinant Human Transcription factor E2F3 (E2F3)

Uniprot Id

O00716

Target Species

Human

Target Name

E2F3

Target Full Name

Transcription factor E2F3

Target Function

Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters.

Target Subcellular Location

Nucleus.

Target Protein Families

E2F/DP family

Target Synonyms

DKFZp686C18211; E2F 3; E2F transcription factor 3; E2F-3; E2F3; E2F3_HUMAN; KIAA0075; MGC104598; Transcription factor E2F 3; Transcription factor E2F3

Target Background

This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants.