Recombinant Human Transcription factor SOX-11 (SOX11)

Uniprot Id

P35716

Target Species

Human

Target Name

SOX11

Target Full Name

Transcription factor SOX-11

Target Function

Transcription factor that acts as a transcriptional activator. Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation. Acts as a transcriptional activator of TEAD2 by binding to its gene promoter and first intron. Plays a redundant role with SOX4 and SOX12 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis.

Target Involvement

Mental retardation, autosomal dominant 27 (MRD27)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Expressed primarily in the brain and heart, with low expression in the kidney, pancreas and muscle.

Target Synonyms

MRD27; SOX11; SOX11_HUMAN; SRY (sex determining region Y) box 11; SRY related HMG box gene 11; SRY-box 11; Transcription factor SOX-11

Target Background

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis.