Recombinant Human Transmembrane protease serine 4 (TMPRSS4), Truncated

Uniprot Id

Q9NRS4

Target Species

Human

Target Name

TMPRSS4

Target Full Name

Transmembrane protease serine 4

Target Function

Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC.; (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry.

Target Subcellular Location

Cell membrane; Single-pass type II membrane protein.; [Transmembrane protease serine 4 catalytic chain]: Secreted.

Target Protein Families

Peptidase S1 family

Target Tissue Specificity

High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract. Coexpressed with ACE2 within mature enterocytes.

Target Research Area

Others

Target Synonyms

UNQ776/PRO1570; CAPH2; Channel-activating protease 2; Membrane type serine protease 2; Membrane-type serine protease 2; MT SP2; MT-SP2; TMPRSS 4; TMPRSS3; TMPRSS4; TMPS4_HUMAN; Transmembrane protease serine 4; Transmembrane protease, serine 4; Transmembrane serine protease 3

Target Background

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. The protein has been found to promote SARS-CoV-2 entry into host cells.