Recombinant Human tRNA N6-adenosine threonylcarbamoyltransferase (OSGEP)

Uniprot Id

Q9NPF4

Target Species

Human

Target Name

OSGEP

Target Full Name

tRNA N6-adenosine threonylcarbamoyltransferase

Target Function

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

KAE1 / TsaD family

Target Tissue Specificity

Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas.

Target Research Area

others

Target Synonyms

FLJ20411; GCPL-1; GCPL1; hOSGEP; KAE1; O sialoglycoprotein endopeptidase; OSGEP; OSGEP_HUMAN; OSGEP1; Pasteurella haemolytica metalloprotease homolog with glycoprotein substrates/gpc-like protein 1; Probable O sialoglycoprotein endopeptidase; Probable tRNA threonylcarbamoyladenosine biosynthesis protein osgep; PRSMG1; Prsmg1/Gcpl1; t(6)A37 threonylcarbamoyladenosine biosynthesis protein osgep

Target Background

Predicted to enable N(6)-L-threonylcarbamoyladenine synthase activity and metal ion binding activity. Involved in tRNA threonylcarbamoyladenosine modification. Located in cytoplasm; nuclear speck; and plasma membrane. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 3.