Recombinant Human tRNA-splicing endonuclease subunit Sen15 (TSEN15)

Uniprot Id

Q8WW01

Target Species

Human

Target Name

TSEN15

Target Full Name

tRNA-splicing endonuclease subunit Sen15

Target Function

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.

Target Involvement

Pontocerebellar hypoplasia 2F (PCH2F)

Target Subcellular Location

Nucleus. Nucleus, nucleolus.

Target Protein Families

SEN15 family

Target Tissue Specificity

Widely expressed. Highly expressed in testis and uterus.

Target Synonyms

TSEN15; C1orf19; SEN15; tRNA-splicing endonuclease subunit Sen15; SEN15 homolog; HsSEN15; tRNA-intron endonuclease Sen15