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| Cat.No | ACP15233 | Target Name | TPH2 |
|---|---|---|---|
| Target Synonyms | TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-490 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IWU9 |
|---|
Uniprot Id
Q8IWU9
Target Species
Human
Target Name
TPH2
Target Full Name
Tryptophan 5-hydroxylase 2
Target Involvement
Major depressive disorder (MDD); Attention deficit-hyperactivity disorder 7 (ADHD7)
Target Protein Families
Biopterin-dependent aromatic amino acid hydroxylase family
Target Tissue Specificity
Brain specific.
Target Research Area
Neuroscience
Target Synonyms
TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
Target Background
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
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