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Discover our high-quality Recombinant Human TNFRSF1A protein, designed to meet the needs of researchers in the field of Apoptosis. This protein represents a partial segment of Tumor necrosis factor receptor superfamily member 1A (CD120a) and is expressed in the E.coli system, covering the 31-210aa region. For ease of protein purification and detection, our TNFRSF1A protein is equipped with an N-terminal GST-tag, ensuring consistent performance throughout your experiments. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human TNFRSF1A protein is available in both liquid and lyophilized powder forms. Trust this exceptional protein to support your Apoptosis research and deliver reliable, high-quality results.
Discover our high-quality Recombinant Human TNFRSF1A protein, designed to meet the needs of researchers in the field of Apoptosis. This protein represents a partial segment of Tumor necrosis factor receptor superfamily member 1A (CD120a) and is expressed in the E.coli system, covering the 31-210aa region. For ease of protein purification and detection, our TNFRSF1A protein is equipped with an N-terminal GST-tag, ensuring consistent performance throughout your experiments.
With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human TNFRSF1A protein is available in both liquid and lyophilized powder forms. Trust this exceptional protein to support your Apoptosis research and deliver reliable, high-quality results.
| Cat.No | ACP02914 | Target Name | TNFRSF1A |
|---|---|---|---|
| Target Synonyms | member 1A; Tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; Tumor necrosis factor-binding protein 1 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 31-210aa |
| Mol Weight | 47.2kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P19438 |
|---|
Uniprot Id
P19438
Target Species
Human
Target Name
TNFRSF1A
Target Full Name
Tumor necrosis factor receptor superfamily member 1A
Target Function
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Target Involvement
Familial hibernian fever (FHF); Multiple sclerosis 5 (MS5)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Secreted. Note=A secreted form is produced through proteolytic processing.; [Isoform 4]: Secreted. Note=Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
Target Research Area
Apoptosis, Signal Transduction
Target Synonyms
CD120a; FPF; MGC19588; p55; p55-R; p60; TBP1; TBPI; TNF R; TNF R55; TNF-R1; TNF-RI; TNFAR; TNFR-I; TNFR1; TNFR55; TNFR60; TNFRI; TNFRSF1a; TNR1A_HUMAN; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor superfamily, member 1A; Tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; Tumor necrosis factor-binding protein 1
Target Background
This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients.
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