Recombinant Human Type I inositol 3,4-bisphosphate 4-phosphatase (INPP4A), Truncated

Uniprot Id

Q96PE3

Target Species

Human

Target Name

INPP4A

Target Full Name

Inositol polyphosphate-4-phosphatase type I A

Target Function

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2). Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current.; Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.

Target Subcellular Location

Early endosome membrane. Recycling endosome membrane. Cell membrane. Nucleus. Cytoplasm. Cell junction, synapse, postsynaptic density.

Target Protein Families

Inositol 3,4-bisphosphate 4-phosphatase family

Target Tissue Specificity

Isoform 1 is expressed in the platelets, MEG-01 megakaryocytes and Jurkat T-cells. Isoform 2 is expressed in the brain.

Target Synonyms

107kDa; 4-bisphosphate 4-phosphatase; 9630012D15; D130048C09Rik; Inositol polyphosphate 4 phosphatase type I 107kDa; Inositol polyphosphate 4 phosphatase type I; Inositol polyphosphate 4-phosphatase type I; INP4A_HUMAN; INPP4; Inpp4a; OTTHUMP00000203138; OTTHUMP00000203139; OTTHUMP00000203141; OTTHUMP00000225217; R74740; TVAS1; Type I inositol 3 4 bisphosphate 4 phosphatase; Type I inositol 3,4 bisphosphate 4 phosphatase; Type I inositol-3

Target Background

This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3, 4-bisphosphate, inositol 1, 3, 4-trisphosphate, and inositol 3, 4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described.