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| Cat.No | ACP15321 | Target Name | PRAG1 |
|---|---|---|---|
| Target Synonyms | Chr 8, D8Ertd82e; DKFZp761P0423; DNA segment, ERATO Doi 82; EC 2.7.10.2; Homolog of rat pragma of Rnd2; LOC157285; PRAGMIN ; SG223_HUMAN; Sgk223; Sugen kinase 223; Tyrosine protein kinase SgK223; Tyrosine-protein kinase SgK223 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q86YV5 |
|---|
Uniprot Id
Q86YV5
Target Species
Human
Target Name
PRAG1
Target Full Name
Inactive tyrosine-protein kinase PRAG1
Target Function
Catalytically inactive protein kinase that acts as a scaffold protein. Functions as an effector of the small GTPase RND2, which stimulates RhoA activity and inhibits NGF-induced neurite outgrowth. Promotes Src family kinase (SFK) signaling by regulating the subcellular localization of CSK, a negative regulator of these kinases, leading to the regulation of cell morphology and motility by a CSK-dependent mechanism. Acts as a critical coactivator of Notch signaling.
Target Subcellular Location
Cytoplasm. Cell junction, focal adhesion. Nucleus.
Target Protein Families
Protein kinase superfamily
Target Synonyms
D8Ertd82e; DKFZp761P0423; DNA segment, Chr 8, ERATO Doi 82; EC 2.7.10.2; Homolog of rat pragma of Rnd2; LOC157285; PRAGMIN ; SG223_HUMAN; Sgk223; Sugen kinase 223; Tyrosine protein kinase SgK223; Tyrosine-protein kinase SgK223
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