Recombinant Human U6 snRNA-associated Sm-like protein LSm1 (LSM1)

Uniprot Id

O15116

Target Species

Human

Target Name

LSM1

Target Full Name

U6 snRNA-associated Sm-like protein LSm1

Target Function

Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation.

Target Subcellular Location

Cytoplasm. Cytoplasm, P-body.

Target Protein Families

SnRNP Sm proteins family

Target Synonyms

Cancer associated Sm like protein; Cancer associated Sm-like; Cancer-associated Sm-like; CASM; lsm1; LSM1; LSM1 homolog; U6 small nuclear RNA associated (S. cerevisiae); Lsm1 protein; LSM1; U6 small nuclear RNA associated; LSM1_HUMAN; Small nuclear ribonuclear CaSm; U6 snRNA associated Sm-like protein LSm1; U6 snRNA-associated Sm-like protein LSm1; YJL124C

Target Background

This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9.