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| Cat.No | ACP16222 | Target Name | USP17L2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-530 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6R6M4 |
|---|
Uniprot Id
Q6R6M4
Target Species
Human
Target Name
USP17L2
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 17
Target Function
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates cell proliferation by deubiquitinating and inhibiting RCE1 thereby controlling the small GTPases NRAS and HRAS localization and activation. In parallel, mediates deubiquitination of CDC25A, preventing CDC25A degradation by the proteasome during the G1/S and G2/M phases promoting cell-cycle progression. Also regulates cell proliferation and apoptosis through deubiquitination of SUDS3 a regulator of histone deacetylation. Through activation of the Rho family GTPases RAC1A, CDC42 and RHOA, regulates cell migration. Through the cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains of the cytoplasmic innate immune receptors DDX58 and IFIH1 stimulates the cellular response to viral infection
Target Subcellular Location
Nucleus. Endoplasmic reticulum.
Target Protein Families
Peptidase C19 family, USP17 subfamily
Target Tissue Specificity
Broadly expressed.
Target Synonyms
USP17L2; DUB3; USP17; USP17H; USP17I; USP17J; USP17K; USP17L; USP17M; Ubiquitin carboxyl-terminal hydrolase 17; USP17; EC 3.4.19.12; Deubiquitinating enzyme 17-like protein 2; Deubiquitinating protein 3; DUB-3; Ubiquitin carboxyl-terminal hydrolase 17-like protein 2; Ubiquitin thioesterase 17-like protein 2; Ubiquitin-specific-processing protease 17-like protein 2
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