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| Cat.No | ACP22482 | Target Name | USP46 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-366 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P62068 |
|---|
Uniprot Id
P62068
Target Species
Human
Target Name
USP46
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 46
Target Function
Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. May act by mediating the deubiquitination of GAD1/GAD67. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2.
Target Protein Families
Peptidase C19 family, USP12/USP46 subfamily
Target Tissue Specificity
Broadly expressed.
Target Synonyms
Deubiquitinating enzyme 46; FLJ11850; FLJ12552; FLJ14283; FLJ39393; Ubiquitin carboxyl terminal hydrolase 46; Ubiquitin carboxyl-terminal hydrolase 46; Ubiquitin specific peptidase 46; Ubiquitin specific processing protease 46; Ubiquitin specific protease 46; Ubiquitin thioesterase 46; Ubiquitin thiolesterase 46; Ubiquitin-specific-processing protease 46; UBP46_HUMAN; USP46
Target Background
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).
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