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| Cat.No | ACP15948 | Target Name | USP51 |
|---|---|---|---|
| Target Synonyms | USP51; Ubiquitin carboxyl-terminal hydrolase 51; EC 3.4.19.12; Deubiquitinating enzyme 51; Ubiquitin thioesterase 51; Ubiquitin-specific-processing protease 51 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-711 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q70EK9 |
|---|
Uniprot Id
Q70EK9
Target Species
Human
Target Name
USP51
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 51
Target Function
Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin.
Target Subcellular Location
Chromosome.
Target Protein Families
Peptidase C19 family
Target Tissue Specificity
Expressed in prostate, brain, lung, aorta and kidney.
Target Synonyms
USP51; Ubiquitin carboxyl-terminal hydrolase 51; EC 3.4.19.12; Deubiquitinating enzyme 51; Ubiquitin thioesterase 51; Ubiquitin-specific-processing protease 51
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