Recombinant Human UDP-glucuronosyltransferase 1A3 (UGT1A3), Truncated

Cat.No	ACP06532	Target Name	UGT1A3
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP06532

Target Name

UGT1A3

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P35503

Background Information

Uniprot Id

P35503
Target Species

Human
Target Name

UGT1A3
Target Full Name

UDP-glucuronosyltransferase 1A3
Target Function

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II.; Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1
Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass membrane protein.
Target Protein Families

UDP-glycosyltransferase family
Target Tissue Specificity

[Isoform 1]: Expressed in liver, kidney, colon, esophagus and small intestine.; [Isoform 2]: Expressed in liver, kidney and colon. Not expressed in esophagus and small intestine.
Target Synonyms

UGT1A3; GNT1; UGT1; UDP-glucuronosyltransferase 1A3; UGT1A3; UDP-glucuronosyltransferase 1-3; UDPGT 1-3; UGT1*3; UGT1-03; UGT1.3; UDP-glucuronosyltransferase 1-C; UGT-1C; UGT1C; UDP-glucuronosyltransferase 1A isoform 3

Recombinant Human UDP-glucuronosyltransferase 1A3 (UGT1A3), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human UDP-glucuronosyltransferase 1A3 (UGT1A3), Truncated Now

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