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| Cat.No | ACP13377 | Target Name | POMGNT2 |
|---|---|---|---|
| Target Synonyms | 4-N-acetylglucosaminyltransferase 2; POMGnT2; EC 2.4.1.312; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2, POMGNT2; AGO61; C3orf39; EOGTL; GTDC2; Protein O-linked-mannose beta-1 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NAT1 |
|---|
Uniprot Id
Q8NAT1
Target Species
Human
Target Name
POMGNT2
Target Full Name
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2
Target Function
O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity.
Target Involvement
Muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies A8 (MDDGA8)
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Target Protein Families
Glycosyltransferase 61 family
Target Tissue Specificity
Highly expressed in the brain, muscle, heart, and kidney in both fetus and adult. In the brain, highest expression in the cortex and cerebellum. Highly expressed in the pancreas.
Target Synonyms
POMGNT2; AGO61; C3orf39; EOGTL; GTDC2; Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; POMGnT2; EC 2.4.1.312; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2
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