Recombinant Human Unconventional myosin-Id (MYO1D), Truncated

Uniprot Id

O94832

Target Species

Human

Target Name

MYO1D

Target Full Name

Unconventional myosin-Id

Target Function

Unconventional myosin that functions as actin-based motor protein with ATPase activity. Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes. Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells.

Target Subcellular Location

Cytoplasm. Perikaryon. Cell projection, dendrite. Early endosome. Cytoplasm, cell cortex.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family

Target Tissue Specificity

Expressed in many tissues. Highest levels in brain, followed by lung and ovary; expression is lowest in spleen.

Target Synonyms

MYO1D; KIAA0727; Unconventional myosin-Id

Target Background

Enables protein domain specific binding activity. Predicted to be involved in actin filament organization; early endosome to recycling endosome transport; and vesicle transport along actin filament. Located in extracellular exosome.