Recombinant Human Unconventional myosin-Ie (MYO1E), Truncated

Uniprot Id

Q12965

Target Species

Human

Target Name

MYO1E

Target Full Name

Unconventional myosin-Ie

Target Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14.

Target Involvement

Focal segmental glomerulosclerosis 6 (FSGS6)

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cell junction.

Target Protein Families

TRAFAC class myosin-kinesin ATPase superfamily, Myosin family

Target Tissue Specificity

Expressed in the immune system. In the kidney, predominantly expressed in the glomerulus, including podocytes.

Target Synonyms

FSGS6; HuncM-IC; MYO1C; Myo1e; MYO1E variant protein; MYO1E_HUMAN; Myosin heavy chain myr 3; Myosin IC, formerly; Myosin IE; Myosin-Ic; Myr 3; Myr3; MYR5; Unconventional myosin 1E; Unconventional myosin Ie; Unconventional myosin-Ie

Target Background

This gene encodes a member of the nonmuscle class I myosins which are a subgroup of the unconventional myosin protein family. The unconventional myosin proteins function as actin-based molecular motors. Class I myosins are characterized by a head (motor) domain, a regulatory domain and a either a short or long tail domain. Among the class I myosins, this protein is distinguished by a long tail domain that is involved in crosslinking actin filaments. This protein localizes to the cytoplasm and may be involved in intracellular movement and membrane trafficking. Mutations in this gene are the cause of focal segmental glomerulosclerosis-6. This gene has been referred to as myosin IC in the literature but is distinct from the myosin IC gene located on chromosome 17.