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Amino acids 1-363 constitute the expression domain of recombinant Human RAD23A. The theoretical molecular weight of the RAD23A protein is 66.6 kDa. This RAD23A recombinant protein is manufactured in e.coli. The RAD23A coding gene included the N-terminal GST tag, which simplifies the detection and purification processes of the recombinant RAD23A protein in following stages of expression and purification.UV excision repair protein RAD23 homolog A (RAD23A) is a multifunctional protein involved in nucleotide excision repair (NER), a DNA repair mechanism that removes damaged nucleotides caused by UV radiation and other genotoxic agents. RAD23A acts as a shuttle protein that participates in the recognition and recruitment of damaged DNA sites during the initial steps of NER. It forms a complex with the Xeroderma Pigmentosum Group C (XPC) protein, aiding in the detection of DNA lesions. Additionally, RAD23A is involved in the delivery of ubiquitinated substrates to the proteasome for degradation. Studies on RAD23A contribute to the understanding of NER and the coordination of DNA repair processes. Aberrations in DNA repair mechanisms, including RAD23A function, are implicated in cancer development. Research explores the potential role of RAD23A in tumorigenesis. RAD23A's involvement in delivering ubiquitinated substrates to the proteasome connects it to cellular protein quality control and degradation pathways.
Amino acids 1-363 constitute the expression domain of recombinant Human RAD23A. The theoretical molecular weight of the RAD23A protein is 66.6 kDa. This RAD23A recombinant protein is manufactured in e.coli. The RAD23A coding gene included the N-terminal GST tag, which simplifies the detection and purification processes of the recombinant RAD23A protein in following stages of expression and purification.UV excision repair protein RAD23 homolog A (RAD23A) is a multifunctional protein involved in nucleotide excision repair (NER), a DNA repair mechanism that removes damaged nucleotides caused by UV radiation and other genotoxic agents. RAD23A acts as a shuttle protein that participates in the recognition and recruitment of damaged DNA sites during the initial steps of NER. It forms a complex with the Xeroderma Pigmentosum Group C (XPC) protein, aiding in the detection of DNA lesions. Additionally, RAD23A is involved in the delivery of ubiquitinated substrates to the proteasome for degradation. Studies on RAD23A contribute to the understanding of NER and the coordination of DNA repair processes. Aberrations in DNA repair mechanisms, including RAD23A function, are implicated in cancer development. Research explores the potential role of RAD23A in tumorigenesis. RAD23A’s involvement in delivering ubiquitinated substrates to the proteasome connects it to cellular protein quality control and degradation pathways.
| Cat.No | ACP02571 | Target Name | RAD23A |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-363aa | Mol Weight | 66.6kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P54725 |
|---|
Uniprot Id
P54725
Target Species
Human
Target Name
RAD23A
Target Full Name
UV excision repair protein RAD23 homolog A
Target Function
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.
Target Subcellular Location
Nucleus.
Target Protein Families
RAD23 family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
hHR 23A; hHR23A; HR23A; MGC111083; RAD 23a; RAD23 homolog A (S. cerevisiae); RAD23 homolog A; RAD23 yeast homolog A; RAD23A; RD23A_HUMAN; UV excision repair protein RAD23; UV excision repair protein RAD23 homolog A
Target Background
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms.
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