Recombinant Human Very long chain fatty acid elongase 5 (ELOVL5)

Cat.No	ACP02181	Target Name	ELOVL5
Target Synonyms	3-keto acyl-CoA synthase ELOVL5;ELOVL fatty acid elongase 5;ELOVL FA elongase 5;Fatty acid elongase 1;hELO1;Very long chain 3-ketoacyl-CoA synthase 5;Very long chain 3-oxoacyl-CoA synthase 5	Form	Liquid or Lyophilized powder
Expression System	in vitro E.coli expression system	Expression Range	1-299aa
Mol Weight	36.8 kDa	Protein Length	Full length
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02181

Target Name

ELOVL5

Target Synonyms

3-keto acyl-CoA synthase ELOVL5;ELOVL fatty acid elongase 5;ELOVL FA elongase 5;Fatty acid elongase 1;hELO1;Very long chain 3-ketoacyl-CoA synthase 5;Very long chain 3-oxoacyl-CoA synthase 5

Form

Liquid or Lyophilized powder

Expression System

in vitro E.coli expression system

Expression Range

1-299aa

Mol Weight

36.8 kDa

Protein Length

Full length

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NYP7

Background Information

Uniprot Id

Q9NYP7
Target Species

Human
Target Name

ELOVL5
Target Full Name

Very long chain fatty acid elongase 5
Target Function

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate in the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In conditions where the essential linoleic and alpha linoleic fatty acids are lacking it is also involved in the synthesis of Mead acid from oleic acid.
Target Involvement

Spinocerebellar ataxia 38 (SCA38)
Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell projection, dendrite.
Target Protein Families

ELO family, ELOVL5 subfamily
Target Tissue Specificity

Ubiquitous. Highly expressed in the adrenal gland and testis. Weakly expressed in prostate, lung and brain. Expressed in the cerebellum.
Target Research Area

Cardiovascular
Target Synonyms

ELOVL5; ELOVL2; PRO0530; Elongation of very long chain fatty acids protein 5; 3-keto acyl-CoA synthase ELOVL5; ELOVL fatty acid elongase 5; ELOVL FA elongase 5; Fatty acid elongase 1; hELO1; Very long chain 3-ketoacyl-CoA synthase 5; Very long chain 3-oxoacyl-CoA synthase 5
Target Background

This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene.

Recombinant Human Very long chain fatty acid elongase 5 (ELOVL5)

Specifications

Immunogen Information

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