Recombinant Human Vesicle-associated membrane protein 4 (VAMP4), Truncated

Uniprot Id

O75379

Target Species

Human

Target Name

VAMP4

Target Full Name

Vesicle-associated membrane protein 4

Target Function

Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.

Target Subcellular Location

Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.

Target Protein Families

Synaptobrevin family

Target Synonyms

VAMP4; Vesicle-associated membrane protein 4; VAMP-4

Target Background

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. This protein may play a role in trans-Golgi network-to-endosome transport.