Recombinant Human Voltage-dependent anion-selective channel protein 3 (VDAC3), Truncated

Uniprot Id

Q9Y277

Target Species

Human

Target Name

VDAC3

Target Full Name

Non-selective voltage-gated ion channel VDAC3

Target Function

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.

Target Subcellular Location

Mitochondrion outer membrane. Membrane.

Target Protein Families

Eukaryotic mitochondrial porin family

Target Tissue Specificity

Expressed in erythrocytes (at protein level). Widely expressed. Highest in testis.

Target Synonyms

VDAC3; Voltage-dependent anion-selective channel protein 3; VDAC-3; hVDAC3; Outer mitochondrial membrane protein porin 3

Target Background

This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.