Recombinant Human WASP homolog-associated protein with actin, membranes and microtubules (WHAMM), Truncated

Uniprot Id

Q8TF30

Target Species

Human

Target Name

WHAMM

Target Full Name

WASP homolog-associated protein with actin, membranes and microtubules

Target Function

Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration

Target Subcellular Location

Cytoplasm. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle membrane. Golgi apparatus, cis-Golgi network.

Target Tissue Specificity

Expressed in brain, lung, heart, colon and kidney (at protein level).

Target Synonyms

KIAA1971; membranes and microtubules; WAS protein homolog associated with actin; golgi membranes and microtubules; WAS protein homology region 2 domain containing 1; WAS protein homology region 2 domain-containing protein 1; WASP homolog-associated protein with actin; WASP homolog-associated protein with actin; membranes and microtubules; WH2 domain-containing protein 1; WHAMM; WHAMM_HUMAN; WHDC1