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The recombinant Human WDR5 was expressed with the amino acid range of 2-334. The expected molecular weight for the WDR5 protein is calculated to be 52.5 kDa. Expression of this WDR5 protein is conducted in e.coli. The N-terminal 6xHis-SUMO tag was smoothly integrated into the coding gene of WDR5, which enables a simple process of detecting and purifying the WDR5 recombinant protein in the following steps.The human WD repeat-containing protein 5 (WDR5) plays a crucial role in epigenetic regulation as a core component of the MLL (Mixed Lineage Leukemia) complex. This complex functions as a histone methyltransferase, specifically catalyzing the methylation of histone H3 at lysine 4 (H3K4), a modification associated with transcriptional activation. WDR5's involvement in the MLL complex highlights its importance in regulating gene expression and chromatin structure. Additionally, WDR5 has been implicated in stem cell maintenance and differentiation, and its dysregulation is associated with various diseases, including cancer. Understanding the functions of WDR5 contributes to unraveling the complexities of epigenetic control and may have implications for therapeutic interventions.
The recombinant Human WDR5 was expressed with the amino acid range of 2-334. The expected molecular weight for the WDR5 protein is calculated to be 52.5 kDa. Expression of this WDR5 protein is conducted in e.coli. The N-terminal 6xHis-SUMO tag was smoothly integrated into the coding gene of WDR5, which enables a simple process of detecting and purifying the WDR5 recombinant protein in the following steps.The human WD repeat-containing protein 5 (WDR5) plays a crucial role in epigenetic regulation as a core component of the MLL (Mixed Lineage Leukemia) complex. This complex functions as a histone methyltransferase, specifically catalyzing the methylation of histone H3 at lysine 4 (H3K4), a modification associated with transcriptional activation. WDR5’s involvement in the MLL complex highlights its importance in regulating gene expression and chromatin structure. Additionally, WDR5 has been implicated in stem cell maintenance and differentiation, and its dysregulation is associated with various diseases, including cancer. Understanding the functions of WDR5 contributes to unraveling the complexities of epigenetic control and may have implications for therapeutic interventions.
| Cat.No | ACP04011 | Target Name | WDR5 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-334aa | Mol Weight | 52.5kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P61964 |
|---|
Uniprot Id
P61964
Target Species
Human
Target Name
WDR5
Target Full Name
WD repeat-containing protein 5
Target Function
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B.
Target Subcellular Location
Nucleus.
Target Protein Families
WD repeat WDR5/wds family
Target Research Area
Transcription
Target Synonyms
2410008O07Rik; AA408785; AA960360; BIG 3; Big; BIG3; BMP2 induced 3 kb gene protein; BMP2 induced gene; 3-KB; BMP2-induced 3-kb gene protein; MGC114572; OTTHUMP00000162494; SWD 3; SWD3; SWD3 Set1c WD40 repeat protein homolog; WD repeat containing protein 5; WD repeat domain 5; WD repeat protein 5; WD repeat-containing protein 5; WD repeat-containing protein BIG-3; WDR 5; Wdr5; WDR5_HUMAN
Target Background
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.
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