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| Cat.No | ACP05728 | Target Name | XKR8 |
|---|---|---|---|
| Target Synonyms | FLJ10307; hXkr8; RP11-460I13.3; X Kell blood group precursor-related family; member 8; XK-related protein 8; XKR8; XKR8_HUMAN; XRG8 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H6D3 |
|---|
Uniprot Id
Q9H6D3
Target Species
Human
Target Name
XKR8
Target Full Name
XK-related protein 8
Target Function
Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Required for the clearance of apoptotic cells, such as engulfment of apoptotic germ cells by Sertoli cells, clearance of senescent neutrophils or regulation of bipolar cell numbers in the retina. Has no effect on calcium-induced exposure of phosphatidylserine. Promotes myoblast differentiation and survival.; (Microbial infection) Incorporated into Ebola virus-like particles, where its phospholipid scramblase activity is required to promote phosphatidylserine exposure on the surface of viral particles. Externalization of phosphatidylserine on the surface of viral particles is required for uptake by host cells.
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region.
Target Protein Families
XK family
Target Synonyms
FLJ10307; hXkr8; RP11-460I13.3; X Kell blood group precursor-related family; member 8; XK-related protein 8; XKR8; XKR8_HUMAN; XRG8
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