Recombinant Human Zinc finger matrin-type protein 3 (ZMAT3)

Uniprot Id

Q9HA38

Target Species

Human

Target Name

ZMAT3

Target Full Name

Zinc finger matrin-type protein 3

Target Function

Acts as a bona fide target gene of p53/TP53. May play a role in the TP53-dependent growth regulatory pathway. May contribute to TP53-mediated apoptosis by regulation of TP53 expression and translocation to the nucleus and nucleolus.

Target Subcellular Location

Nucleus. Nucleus, nucleolus.

Target Tissue Specificity

Highly expressed in adult brain, and moderately in adult kidney and testis. Not detected in fetal brain, heart, pancreas, adrenal gland, liver or small intestine.

Target Synonyms

FLJ12296; FLJ31683; MGC10613; OTTHUMP00000211906; OTTHUMP00000211907; p53 activated gene 608; p53 inducible zinc finger protein; p53 target zinc finger protein; p53-activated gene 608 protein; PAG 608; WIG 1; WIG 1/PAG608 protein; WIG1; WIG1/PAG608 protein; Wildtype p53-induced gene; Zinc finger matrin type 3; Zinc finger matrin-type protein 3; Zinc finger protein WIG 1; Zinc finger protein WIG-1; Zinc finger protein WIG1; ZMAT 3; Zmat3; ZMAT3_HUMAN

Target Background

This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid.