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Amino acids 921-1106 form the expressed segment for recombinant Human GLI1. The expected molecular weight for the GLI1 protein is calculated to be 23.3 kDa. Expression of this GLI1 protein is conducted in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of GLI1, making it easier to detect and purify the GLI1 recombinant protein in the later stages of expression and purification.The human Zinc finger protein GLI1 is a transcription factor and a key mediator of the Hedgehog signaling pathway. GLI1 plays a critical role in various developmental processes and cell fate determination. GLI1 contains zinc finger DNA-binding domains and acts downstream of Hedgehog ligands. When the Hedgehog pathway is activated, GLI1 translocates to the nucleus, where it regulates the expression of target genes involved in cell proliferation, differentiation, and survival. Dysregulation of GLI1 is associated with various cancers, making it a potential target for cancer therapeutics. Research on Zinc finger protein GLI1 focuses on understanding its precise roles in development, tissue homeostasis, and its implications in cancer progression.
Amino acids 921-1106 form the expressed segment for recombinant Human GLI1. The expected molecular weight for the GLI1 protein is calculated to be 23.3 kDa. Expression of this GLI1 protein is conducted in e.coli. The N-terminal 6xHis tag was fused into the coding gene segment of GLI1, making it easier to detect and purify the GLI1 recombinant protein in the later stages of expression and purification.The human Zinc finger protein GLI1 is a transcription factor and a key mediator of the Hedgehog signaling pathway. GLI1 plays a critical role in various developmental processes and cell fate determination. GLI1 contains zinc finger DNA-binding domains and acts downstream of Hedgehog ligands. When the Hedgehog pathway is activated, GLI1 translocates to the nucleus, where it regulates the expression of target genes involved in cell proliferation, differentiation, and survival. Dysregulation of GLI1 is associated with various cancers, making it a potential target for cancer therapeutics. Research on Zinc finger protein GLI1 focuses on understanding its precise roles in development, tissue homeostasis, and its implications in cancer progression.
| Cat.No | ACP02851 | Target Name | GLI1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 921-1106aa | Mol Weight | 23.3kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P08151 |
|---|
Uniprot Id
P08151
Target Species
Human
Target Name
GLI1
Target Full Name
Zinc finger protein GLI1
Target Function
Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3'. Regulates the transcription of specific genes during normal development. Plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling.; Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.
Target Subcellular Location
Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.
Target Protein Families
GLI C2H2-type zinc-finger protein family
Target Tissue Specificity
Detected in testis (at protein level). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract. Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and place
Target Research Area
Developmental Biology
Target Synonyms
Gli 1; GLI; GLI family zinc finger 1; GLI Kruppel family member 1; gli1; GLI1_HUMAN; Glioma associated oncogene 1; Glioma associated oncogene homolog 1 (zinc finger protein) ; Glioma associated oncogene homolog; Glioma-associated oncogene; Oncogene GLI; Zfp 5; Zfp5; Zinc finger protein GLI 1; Zinc finger protein GLI1
Target Background
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene.
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