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Recombinant Human Zinc finger protein GLIS2 (GLIS2)

ACP12311

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Specifications

Cat.No	ACP12311	Target Name	GLIS2
Target Synonyms	FLJ38247; GLI similar 2; GLI-similar 2; GLIS 2; GLIS family zinc finger 2; glis2; GLIS2_HUMAN; Kruppel like zinc finger protein GLIS2; Neuronal Krueppel-like protein; Zinc finger protein GLIS2	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-524
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9BZE0

Background Information

Uniprot Id

Q9BZE0
Target Species

Human
Target Name

GLIS2
Target Full Name

Zinc finger protein GLIS2
Target Function

Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation.
Target Involvement

Nephronophthisis 7 (NPHP7)
Target Subcellular Location

Nucleus speckle. Cytoplasm.
Target Protein Families

GLI C2H2-type zinc-finger protein family
Target Tissue Specificity

Expressed at high levels in kidney and at low levels in heart, lung and placenta. Expressed in colon.
Target Synonyms

FLJ38247; GLI similar 2; GLI-similar 2; GLIS 2; GLIS family zinc finger 2; glis2; GLIS2_HUMAN; Kruppel like zinc finger protein GLIS2; Neuronal Krueppel-like protein; Zinc finger protein GLIS2

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Recombinant Human Zinc finger protein GLIS2 (GLIS2)

Specifications

Immunogen Information

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