Recombinant Human Zinc finger protein GLIS3 (GLIS3)

Uniprot Id

Q8NEA6

Target Species

Human

Target Name

GLIS3

Target Full Name

Zinc finger protein GLIS3

Target Function

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'.

Target Involvement

Diabetes mellitus, neonatal, with congenital hypothyroidism (NDH)

Target Subcellular Location

Nucleus.

Target Protein Families

GLI C2H2-type zinc-finger protein family

Target Tissue Specificity

In the adult, expressed at high levels in the kidney and at lower levels in the brain, skeletal muscle, pancreas, liver, lung, thymus and ovary.

Target Synonyms

GLIS3; ZNF515; Zinc finger protein GLIS3; GLI-similar 3; Zinc finger protein 515

Target Background

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined.