Recombinant Human Zinc finger protein ZFPM2 (ZFPM2), Truncated

Uniprot Id

Q8WW38

Target Species

Human

Target Name

ZFPM2

Target Full Name

Zinc finger protein ZFPM2

Target Function

Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.

Target Involvement

Tetralogy of Fallot (TOF); Diaphragmatic hernia 3 (DIH3); 46,XY sex reversal 9 (SRXY9); Conotruncal heart malformations (CTHM)

Target Subcellular Location

Nucleus.

Target Protein Families

FOG (Friend of GATA) family

Target Tissue Specificity

Widely expressed at low level.

Target Synonyms

FOG-2; FOG2_HUMAN; Friend of GATA 2; Friend of GATA protein 2; Friend of GATA2; hFOG-2; ZFPM2; Zinc finger protein 89B; Zinc finger protein M2; Zinc finger protein multitype 2; Zinc finger protein ZFPM2

Target Background

The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence.