Platelet-Derived Growth Factor Receptor-Like Protein (PDGFRL) Reagents

Platelet-derived growth factor receptor-like protein

Colorectal cancer (CRC)

Secreted.

Expressed in colon, lung and liver.

PDGF receptor beta like tumor suppressor ; PDGF receptor beta-like tumor suppressor; PDGFR-like protein; Pdgfrl; PDGRL; PGFRL_HUMAN; Platelet-derived growth factor receptor-like protein; PRLTS

This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor.