Rabbit anti-Human Ezrin Monoclonal Antibody

The antibody against Ezrin was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 300-400 of human Ezrin (P15311) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-13620A

Number

Cat.No	ADA-13620A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	Ezrin
Target Synonyms	CVL; CVIL; VIL2; HEL-S-105; Ezrin	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HCT116	Application	ELISA, WB, IHC-P

Cat.No

ADA-13620A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

Ezrin

Target Synonyms

CVL; CVIL; VIL2; HEL-S-105; Ezrin

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HCT116

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Ezrin (P15311).	Target Species	Human
Immunogen Sequence	IEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAK	Uniprot ID	P15311

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Ezrin (P15311).

Target Species

Human

Immunogen Sequence

IEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAK

Uniprot ID

P15311

Background Information

Uniprot Id

P15311
Target Species

Human
Target Name

EZR
Target Full Name

Ezrin
Target Function

Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Target Subcellular Location

Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell projection, microvillus.
Target Tissue Specificity

Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component
Target Research Area

Cell Cycle
Target Synonyms

Villin 2 ezrin; CVIL; CVL; Cytovillin 2; Cytovillin; DKFZp762H157; Epididymis secretory protein Li 105; EZR; EZRI_HUMAN; Ezrin; FLJ26216; HEL S 105; MGC1584; p81; VIL 2; VIL2; Villin 2 (ezrin); Villin 2; Villin-2; Villin2
Target Background

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

Rabbit anti-Human Ezrin Monoclonal Antibody

Specifications

Immunogen Information

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