Recombinant Human Homer protein homolog 2 (HOMER2)

Uniprot Id

Q9NSB8

Target Species

Human

Target Name

HOMER2

Target Full Name

Homer protein homolog 2

Target Function

Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses. Required for normal hearing. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.

Target Involvement

Deafness, autosomal dominant, 68 (DFNA68)

Target Subcellular Location

Cytoplasm. Cell membrane. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.

Target Protein Families

Homer family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

HOMER2; Homer protein homolog 2; Homer-2; Cupidin