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The recombinant Human SLC30A10 protein production is accomplished by manipulating the expression of the desired gene in e.coli cells. The sequence (300-485aa) of foreign DNA is incorporated into an expression vector and subsequently introduced into e.coli cells. Positive cells are selected and cultured to induce the expression of the desired protein. The protein carries a N-terminal 10xHis tag and C-terminal Myc tag. The resulting recombinant Human SLC30A10 protein undergoes affinity purification, with a purity surpassing 90%, as measured by SDS-PAGE.
The recombinant Human SLC30A10 protein production is accomplished by manipulating the expression of the desired gene in e.coli cells. The sequence (300-485aa) of foreign DNA is incorporated into an expression vector and subsequently introduced into e.coli cells. Positive cells are selected and cultured to induce the expression of the desired protein. The protein carries a N-terminal 10xHis tag and C-terminal Myc tag. The resulting recombinant Human SLC30A10 protein undergoes affinity purification, with a purity surpassing 90%, as measured by SDS-PAGE.
| Cat.No | ACP01193 | Target Name | SLC30A10 |
|---|---|---|---|
| Target Synonyms | (ZnT-10)(Manganese transporter SLC30A10)(Solute carrier family 30 member 10) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 300-485aa |
| Mol Weight | 27.9 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6XR72 |
|---|
Uniprot Id
Q6XR72
Target Species
Human
Target Name
SLC30A10
Target Full Name
Calcium/manganese antiporter SLC30A10
Target Function
Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death. Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells.
Target Involvement
Hypermanganesemia with dystonia 1 (HMNDYT1)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network. Recycling endosome. Early endosome.
Target Protein Families
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
Target Tissue Specificity
Specifically expressed in fetal liver and fetal brain. Expressed in adult tissues with relative levels small intestine > liver > testes > brain > ovary > colon > cervix > prostate > placenta.
Target Research Area
Others
Target Synonyms
SLC30A10; ZNT10; ZNT8; Zinc transporter 10; ZnT-10; Manganese transporter SLC30A10; Solute carrier family 30 member 10
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