Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The recombinant Human CHRNA3 was expressed with the amino acid range of 32-240. The theoretical molecular weight of the CHRNA3 protein is 44.6 kDa. Expression of this CHRNA3 protein is conducted in e.coli. The CHRNA3 gene fragment has been modified by fusing the N-terminal 10xHis-SUMO tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant CHRNA3 protein during the following stages.The human neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) plays a pivotal role in neurotransmission as a component of the nicotinic acetylcholine receptor (nAChR). Activation of nAChRs, including CHRNA3, by acetylcholine or nicotine leads to the influx of ions, particularly sodium and calcium, causing membrane depolarization. This activity is fundamental for synaptic transmission, synaptic plasticity, and various cognitive functions within the central nervous system. Research areas involving CHRNA3 are diverse and include studies related to neurobiology, addiction, and neurodegenerative diseases. Furthermore, genetic variations in CHRNA3 have been associated with nicotine dependence and lung cancer susceptibility, making it a significant target in both neurological and pathological research.
The recombinant Human CHRNA3 was expressed with the amino acid range of 32-240. The theoretical molecular weight of the CHRNA3 protein is 44.6 kDa. Expression of this CHRNA3 protein is conducted in e.coli. The CHRNA3 gene fragment has been modified by fusing the N-terminal 10xHis-SUMO tag and C-terminal Myc tag, providing convenience in detecting and purifying the recombinant CHRNA3 protein during the following stages.The human neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) plays a pivotal role in neurotransmission as a component of the nicotinic acetylcholine receptor (nAChR). Activation of nAChRs, including CHRNA3, by acetylcholine or nicotine leads to the influx of ions, particularly sodium and calcium, causing membrane depolarization. This activity is fundamental for synaptic transmission, synaptic plasticity, and various cognitive functions within the central nervous system. Research areas involving CHRNA3 are diverse and include studies related to neurobiology, addiction, and neurodegenerative diseases. Furthermore, genetic variations in CHRNA3 have been associated with nicotine dependence and lung cancer susceptibility, making it a significant target in both neurological and pathological research.
| Cat.No | ACP02263 | Target Name | CHRNA3 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 32-240aa | Mol Weight | 44.6kDa |
| Protein Length | Extracellular Domain | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P32297 |
|---|
Uniprot Id
P32297
Target Species
Human
Target Name
CHRNA3
Target Full Name
Neuronal acetylcholine receptor subunit alpha-3
Target Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Target Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-3/CHRNA3 sub-subfamily
Target Research Area
Neuroscience
Target Synonyms
ACHA3_HUMAN; AChR; Cholinergic receptor neuronal nicotinic alpha polypeptide 3; Cholinergic receptor nicotinic alpha 3; Cholinergic receptor nicotinic alpha polypeptide 3; CHRNA 3; CHRNA3; LNCR2; MGC104879; NACHRA 3; NACHRA3; Neuronal acetylcholine receptor protein alpha 3 chain precursor; Neuronal acetylcholine receptor subunit alpha 3; Neuronal acetylcholine receptor subunit alpha-3; Neuronal nicotinic acetylcholine receptor alpha 3 subunit; PAOD2
Target Background
This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
