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Recombinant Human Hereditary hemochromatosis protein (HFE), Truncated

ACP02375

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Specifications

Cat.No	ACP02375	Target Name	HFE
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	23-306aa	Mol Weight	40.2 kDa
Protein Length	Extracellular Domain	Purity	Greater than 85% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q30201

Background Information

Uniprot Id

Q30201
Target Species

Human
Target Name

HFE
Target Full Name

Hereditary hemochromatosis protein
Target Function

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin.
Target Involvement

Hemochromatosis 1 (HFE1); Variegate porphyria (VP); Microvascular complications of diabetes 7 (MVCD7)
Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.
Target Protein Families

MHC class I family
Target Tissue Specificity

Expressed in all tissues tested except brain.
Target Research Area

Metabolism
Target Synonyms

dJ221C16.10.1; Hemochromatosis; Hemochromatosis protein; Hereditary hemochromatosis protein; Hereditary hemochromatosis protein HLA H; HFE 1; HFE; HFE_HUMAN; HFE1; HH; High Fe; HLA H; HLA-H; HLAH; MGC:150812; MGC10379; MGC103790; MHC class I like protein HFE; MVCD7; TFQTL2
Target Background

The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene.

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Recombinant Human Hereditary hemochromatosis protein (HFE), Truncated

Specifications

Immunogen Information

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