Recombinant Human Corticosteroid-binding globulin (SERPINA6)

Amino acids 23-405 constitute the expression domain of recombinant Human SERPINA6. This SERPINA6 protein is expected to have a theoretical molecular weight of 69.6 kDa. This SERPINA6 recombinant protein is manufactured in e.coli. The SERPINA6 coding gene included the N-terminal GST tag, which simplifies the detection and purification processes of the recombinant SERPINA6 protein in following stages of expression and purification.Corticosteroid-binding globulin (SERPINA6) is a glycoprotein primarily synthesized in the liver and belongs to the serine protease inhibitor (serpin) superfamily. Its main function is to bind and transport corticosteroids, such as cortisol and corticosterone, in the bloodstream. By forming stable complexes with these hormones, SERPINA6 modulates their availability and influences their distribution to target tissues. This protein is essential in regulating the levels of circulating corticosteroids, impacting various physiological processes like immune response, metabolism, and stress adaptation. Research on SERPINA6 extends to understanding its role in endocrine homeostasis, stress-related disorders, and inflammatory conditions, shedding light on potential therapeutic applications related to corticosteroid balance in different medical contexts.