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The recombinant Human AHSA1 protein synthesis in e.coli cells necessitates the incorporation of a DNA fragment encoding the Human AHSA1 protein (1-338aa) into a plasmid vector, followed by the transformation of this vector into e.coli cells. After screening for positive cells, they are cultured and induced to express the AHSA1 protein. The protein carries a N-terminal GST tag. Cell lysis is performed to gather the recombinant Human AHSA1 protein, which undergoes affinity purification and is then analyzed using SDS-PAGE and subsequent staining of the gel with Coomassie Brilliant Blue. The purity of the resulting recombinant Human AHSA1 protein reaches up to 90%.
The recombinant Human AHSA1 protein synthesis in e.coli cells necessitates the incorporation of a DNA fragment encoding the Human AHSA1 protein (1-338aa) into a plasmid vector, followed by the transformation of this vector into e.coli cells. After screening for positive cells, they are cultured and induced to express the AHSA1 protein. The protein carries a N-terminal GST tag. Cell lysis is performed to gather the recombinant Human AHSA1 protein, which undergoes affinity purification and is then analyzed using SDS-PAGE and subsequent staining of the gel with Coomassie Brilliant Blue. The purity of the resulting recombinant Human AHSA1 protein reaches up to 90%.
| Cat.No | ACP02947 | Target Name | AHSA1 |
|---|---|---|---|
| Target Synonyms | Activator of 90 kDa heat shock protein ATPase homolog 1; Activator of heat shock 90kDa protein ATPase homolog 1; AHA 1; AHA1; AHSA 1; Ahsa1; AHSA1_HUMAN; C14orf3; HSPC322; p38 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-338aa |
| Mol Weight | 65.3kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95433 |
|---|
Uniprot Id
O95433
Target Species
Human
Target Name
AHSA1
Target Full Name
Activator of 90 kDa heat shock protein ATPase homolog 1
Target Function
Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins.
Target Subcellular Location
Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum.
Target Protein Families
AHA1 family
Target Tissue Specificity
Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
Target Research Area
Neuroscience
Target Synonyms
Activator of 90 kDa heat shock protein ATPase homolog 1; Activator of heat shock 90kDa protein ATPase homolog 1; AHA 1; AHA1; AHSA 1; Ahsa1; AHSA1_HUMAN; C14orf3; HSPC322; p38
Target Background
Enables ATPase activator activity; Hsp90 protein binding activity; and chaperone binding activity. Involved in positive regulation of ATPase activity. Located in cytosol.
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