Recombinant Human Mitotic spindle-associated MMXD complex subunit MIP18 (FAM96B)

Uniprot Id

Q9Y3D0

Target Species

Human

Target Name

CIAO2B

Target Full Name

Cytosolic iron-sulfur assembly component 2B

Target Function

Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis.

Target Subcellular Location

Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.

Target Protein Families

MIP18 family

Target Research Area

Cell Biology

Target Synonyms

CGI 128; FAM96B; Family with sequence similarity 96; member B; HSPC118; Hypothetical protein LOC51647; MIP18; MIP18_HUMAN; Mitotic spindle-associated MMXD complex subunit MIP18; MSS19-interacting protein of 18 kDa; Protein FAM96B

Target Background

Involved in chromosome segregation; iron-sulfur cluster assembly; and protein maturation by iron-sulfur cluster transfer. Located in cytosol; nucleoplasm; and spindle. Part of CIA complex and MMXD complex.