Recombinant Human Prestin (SLC26A5), Truncated,Yeast

Uniprot Id

P58743

Target Species

Human

Target Name

SLC26A5

Target Full Name

Prestin

Target Function

Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. Prestin is a bidirectional voltage-to-force converter, it can operate at microsecond rates. It uses cytoplasmic anions as extrinsic voltage sensors, probably chloride and bicarbonate. After binding to a site with millimolar affinity, these anions are translocated across the membrane in response to changes in the transmembrane voltage. They move towards the extracellular surface following hyperpolarization, and towards the cytoplasmic side in response to depolarization. As a consequence, this translocation triggers conformational changes in the protein that ultimately alter its surface area in the plane of the plasma membrane. The area decreases when the anion is near the cytoplasmic face of the membrane (short state), and increases when the ion has crossed the membrane to the outer surface (long state). So, it acts as an incomplete transporter. It swings anions across the membrane, but does not allow these anions to dissociate and escape to the extracellular space. Salicylate, an inhibitor of outer hair cell motility, acts as competitive antagonist at the prestin anion-binding site.

Target Involvement

Deafness, autosomal recessive, 61 (DFNB61)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

SLC26A/SulP transporter (TC 2.A.53) family

Target Research Area

Neuroscience

Target Synonyms

SLC26A5; PRESPrestin; Solute carrier family 26 member 5