Recombinant Human Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (SUCLG2), Truncated

Uniprot Id

Q96I99

Target Species

Human

Target Name

SUCLG2

Target Full Name

Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

Target Function

GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Target Subcellular Location

Mitochondrion.

Target Protein Families

Succinate/malate CoA ligase beta subunit family, GTP-specific subunit beta subfamily

Target Tissue Specificity

Mainly expressed in liver, kidney, heart, spleen and skeletal muscle. Also found in intestine and colon, and in low amounts in lung, brain, prostate, testis and ovary.

Target Research Area

Metabolism

Target Synonyms

EC 6.2.1.4 ; G BETA; GBETA; GTP specific succinyl-CoA synthetase beta subunit; GTP specific succinyl-CoA synthetase subunit beta; GTP-specific succinyl-CoA synthetase subunit beta; mitochondrial; SCS betaG ; SCS-betaG; SUCB2_HUMAN; Succinate CoA ligase GDP forming beta subunit; Succinate-Coenzyme A ligase; GDP-forming; beta subunit; Succinyl CoA ligase GDP forming beta chain mitochondrial ; Succinyl CoA synthetase betaG chain; Succinyl-CoA ligase [GDP-forming] subunit beta; Succinyl-CoA ligase [GDP-forming] subunit beta; mitochondrial; Succinyl-CoA synthetase beta-G chain; SUCLG2

Target Background

This gene encodes a GTP-specific beta subunit of succinyl-CoA synthetase. Succinyl-CoA synthetase catalyzes the reversible reaction involving the formation of succinyl-CoA and succinate. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 5 and 12.