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The recombinant Human UBE2V2 was expressed with the amino acid range of 2-145. This UBE2V2 protein is theoretically predicted to have a molecular weight of 32.2 kDa. This UBE2V2 protein is produced using e.coli expression system. The N-terminal 6xHis-SUMO tag was smoothly integrated into the coding gene of UBE2V2, which enables a simple process of detecting and purifying the UBE2V2 recombinant protein in the following steps.The human ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2), a member of the ubiquitin-conjugating enzyme (E2) family, is involved in the ubiquitin-proteasome system, a cellular mechanism responsible for the targeted degradation of proteins. UBE2V2 plays a crucial role in the formation of polyubiquitin chains, which serve as signals for protein degradation. Specifically, UBE2V2 functions as a ubiquitin-conjugating enzyme variant, working in conjunction with UBE2V1 to catalyze the synthesis of polyubiquitin chains. These chains are then attached to target proteins, marking them for degradation by the proteasome. The ubiquitin-proteasome system is vital for maintaining cellular homeostasis and regulating various processes such as cell cycle progression, signal transduction, and response to cellular stress. Research areas involving UBE2V2 often focus on understanding the molecular mechanisms of protein degradation and its implications in cellular functions and diseases.
The recombinant Human UBE2V2 was expressed with the amino acid range of 2-145. This UBE2V2 protein is theoretically predicted to have a molecular weight of 32.2 kDa. This UBE2V2 protein is produced using e.coli expression system. The N-terminal 6xHis-SUMO tag was smoothly integrated into the coding gene of UBE2V2, which enables a simple process of detecting and purifying the UBE2V2 recombinant protein in the following steps.The human ubiquitin-conjugating enzyme E2 variant 2 (UBE2V2), a member of the ubiquitin-conjugating enzyme (E2) family, is involved in the ubiquitin-proteasome system, a cellular mechanism responsible for the targeted degradation of proteins. UBE2V2 plays a crucial role in the formation of polyubiquitin chains, which serve as signals for protein degradation. Specifically, UBE2V2 functions as a ubiquitin-conjugating enzyme variant, working in conjunction with UBE2V1 to catalyze the synthesis of polyubiquitin chains. These chains are then attached to target proteins, marking them for degradation by the proteasome. The ubiquitin-proteasome system is vital for maintaining cellular homeostasis and regulating various processes such as cell cycle progression, signal transduction, and response to cellular stress. Research areas involving UBE2V2 often focus on understanding the molecular mechanisms of protein degradation and its implications in cellular functions and diseases.
| Cat.No | ACP04134 | Target Name | UBE2V2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-145aa | Mol Weight | 32.2kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q15819 |
|---|
Uniprot Id
Q15819
Target Species
Human
Target Name
UBE2V2
Target Full Name
Ubiquitin-conjugating enzyme E2 variant 2
Target Function
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Target Protein Families
Ubiquitin-conjugating enzyme family
Target Tissue Specificity
Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
1 alpha 25 dihydroxyvitamin D3 inducible; DDVit 1; DDVIT1; EDAF-1; EDAF1; EDPF-1; EDPF1; Enterocyte differentiation associated factor EDAF 1; Enterocyte differentiation promoting factor; Enterocyte differentiation-associated factor 1; Enterocyte differentiation-promoting factor 1; Methyl methanesulfonate sensitive 2; MMS 2; MMS2; MMS2 homolog; UB2V2_HUMAN; UBE2V 2; UBE2V2; Ubiquitin conjugating enzyme E2 variant 2; Ubiquitin conjugating enzyme E2v2; Ubiquitin-conjugating enzyme E2 variant 2; UEV 2; UEV2; Vitamin D3 inducible protein; Vitamin D3-inducible protein
Target Background
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.
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