Recombinant Human Solute carrier family 22 member 8 (SLC22A8), Truncated

Uniprot Id

Q8TCC7

Target Species

Human

Target Name

SLC22A8

Target Full Name

Organic anion transporter 3

Target Function

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).

Target Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein.

Target Protein Families

Major facilitator (TC 2.A.1) superfamily, Organic cation transporter (TC 2.A.1.19) family

Target Tissue Specificity

Expressed in kidney.

Target Synonyms

hOAT3; OAT3 ; Organic anion transporter 3; S22A8_HUMAN; SLC22A8; Solute carrier family 22 (organic anion transporter); member 8; Solute carrier family 22 member 8

Target Background

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.