Recombinant Human Testis anion transporter 1 (SLC26A8), Truncated

Uniprot Id

Q96RN1

Target Species

Human

Target Name

SLC26A8

Target Full Name

Testis anion transporter 1

Target Function

Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation.

Target Involvement

Spermatogenic failure 3 (SPGF3)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

SLC26A/SulP transporter (TC 2.A.53) family

Target Tissue Specificity

Expression observed exclusively in testis, restricted to the meiotic phase of the germ cell. Abundant expression located in the seminiferous tubules, concentrated on the luminal side of the tubuli harboring the spermatocytes and spermatids. Expressed in s

Target Synonyms

SLC26A8; TAT1; Testis anion transporter 1; Anion exchange transporter; Solute carrier family 26 member 8