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| Cat.No | ACP07273 | Target Name | SMDT1 |
|---|---|---|---|
| Target Synonyms | mitochondrial, mitochondrial; Single-pass membrane protein with aspartate-rich tail 1, SMDT1; C22orf32; EMRE; Essential MCU regulator | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H4I9 |
|---|
Uniprot Id
Q9H4I9
Target Species
Human
Target Name
SMDT1
Target Full Name
Essential MCU regulator, mitochondrial
Target Function
Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 and MICU2 with the calcium-conducting subunit MCU. Plays a central role in regulating the uniplex complex response to intracellular calcium signaling. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling.
Target Subcellular Location
Mitochondrion inner membrane; Single-pass membrane protein.
Target Protein Families
SMDT1/EMRE family
Target Synonyms
SMDT1; C22orf32; EMRE; Essential MCU regulator, mitochondrial; Single-pass membrane protein with aspartate-rich tail 1, mitochondrial
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