Recombinant Human Small conductance calcium-activated potassium channel protein 3 (KCNN3), Truncated

Uniprot Id

Q9UGI6

Target Species

Human

Target Name

KCNN3

Target Full Name

Small conductance calcium-activated potassium channel protein 3

Target Function

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Potassium channel KCNN family, KCa2.3/KCNN3 subfamily

Target Synonyms

KCNN3; K3; Small conductance calcium-activated potassium channel protein 3; SK3; SKCa 3; SKCa3; KCa2.3

Target Background

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.