Recombinant Human E3 ubiquitin-protein ligase TRIM17 (TRIM17)

Cat.No	ACP09443	Target Name	TRIM17
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-477	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP09443

Target Name

TRIM17

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-477

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9Y577

Background Information

Uniprot Id

Q9Y577
Target Species

Human
Target Name

TRIM17
Target Full Name

E3 ubiquitin-protein ligase TRIM17
Target Function

E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation. Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1. Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells. Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1.
Target Subcellular Location

Cytoplasm. Lysosome.
Target Protein Families

TRIM/RBCC family
Target Tissue Specificity

Almost exclusively in the testis.
Target Synonyms

E3 ubiquitin-protein ligase TRIM17; RBCC; RING finger protein 16; RING finger protein terf; RNF16; TERF; Testis RING finger protein; TRI17_HUMAN; TRIM 17; Trim17; Tripartite motif containing 17; Tripartite motif containing protein 17; Tripartite motif protein 17; Tripartite motif-containing protein 17
Target Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein is expressed almost exclusively in the testis, but its function is unknown. Multiple alternatively spliced transcript variants have been found for this gene.

Recombinant Human E3 ubiquitin-protein ligase TRIM17 (TRIM17)

Specifications

Immunogen Information

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