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| Cat.No | ACP10444 | Target Name | SIKE1 |
|---|---|---|---|
| Target Synonyms | SIKE1; SIKE; Suppressor of IKBKE 1; Suppressor of IKK-epsilon | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-207 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BRV8 |
|---|
Uniprot Id
Q9BRV8
Target Species
Human
Target Name
SIKE1
Target Full Name
Suppressor of IKBKE 1
Target Function
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
Target Subcellular Location
Cytoplasm.
Target Protein Families
SIKE family
Target Tissue Specificity
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).
Target Synonyms
SIKE1; SIKE; Suppressor of IKBKE 1; Suppressor of IKK-epsilon
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