Recombinant Human PTB domain-containing engulfment adapter protein 1 (GULP1)

Uniprot Id

Q9UBP9

Target Species

Human

Target Name

GULP1

Target Full Name

PTB domain-containing engulfment adapter protein 1

Target Function

May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.

Target Subcellular Location

Cytoplasm. Note=May associate with the cytoplasmic side of the plasma membrane and early endosomes.

Target Protein Families

Ced-6 family

Target Tissue Specificity

Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.

Target Synonyms

CED6; Cell death protein 6 homolog; Engulfment adapter protein; Engulfment adaptor PTB domain containing 1; GULP; GULP; engulfment adaptor PTB domain containing 1; GULP1; GULP1_HUMAN; Protein GULP; PTB domain adapter protein CED 6; PTB domain adapter protein CED-6; PTB domain adaptor protein CED6; PTB domain-containing engulfment adapter protein 1

Target Background

The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene.