Recombinant Human HERV-H_2q24.3 provirus ancestral Env polyprotein, Truncated

Uniprot Id

Q9N2K0

Target Species

Human

Target Name

ENH1

Target Full Name

HERV-H_2q24.3 provirus ancestral Env polyprotein

Target Function

Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties but has immunosuppressive properties in vivo.; SU mediates receptor recognition.; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.

Target Subcellular Location

Virion.; [Transmembrane protein]: Cell membrane; Single-pass membrane protein.

Target Protein Families

Gamma type-C retroviral envelope protein family, HERV class-I H env subfamily

Target Tissue Specificity

Low expression in skin and testis. No expression in several cell lines.

Target Synonyms

HERV-H_2q24.3 provirus ancestral Env polyprotein; Env protein HERV-H/p62; Env protein HERV-H19; Env protein HERV-Hcl.3; Envelope polyprotein; HERV-H/env62) [Cleaved into: Surface protein; SU); Transmembrane protein; TM)]