Recombinant Human UPF0614 protein C14orf102 (C14orf102), Truncated

Uniprot Id

Q9H7Z3

Target Species

Human

Target Name

NRDE2

Target Full Name

Nuclear exosome regulator NRDE2

Target Function

Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm. U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis. Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites. Plays a role in DNA damage response

Target Subcellular Location

Nucleus speckle. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus.

Target Protein Families

NRDE2 family

Target Synonyms

C14orf102; FLJ10008; FLJ14051; NRDE-2, necessary for RNA interference, domain containing; nrdE2; NRDE2_HUMAN; Protein NRDE2 homolog; UPF0614 protein C14orf102